Elaine F Reed, United States

Professor of Pathology and Laboratory Medicine
UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine
University of California Los Angeles

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Dr. Elaine Reed's research efforts are focused on understanding the mechanism of organ allograft rejection. The researchers' studies have shown that binding of antibodies to distinct HLA class I and class II molecules on endothelial cells triggers a series of intracellular signaling cascades resulting in endothelial cell activation, migration, proliferation and enhanced leukocyte recruitment contributing to antibody-mediated graft rejection. Current efforts are focused on elucidating the co-receptors that cooperate with HLA molecules to elicit pathogenic signals contributing to rejection. Understanding these mechanisms will permit the development of new therapeutic modalities for the treatment and prevention of transplant atherosclerosis and the extension of functional life of transplanted organs. An additional focus of Reed's research is in the development of methods for immunologic assessment of the healthy versus unhealthy immune system in various immune, infectious and inflammatory disorders including ischemia reperfusion injury, CMV viremia and bacterial infection.



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